Papers.

• Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors 1,756 citations
• Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia 1,755 citations
• Composition, variability, and temporal stability of the intestinal microbiota of the elderly 1,754 citations
• Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations 1,754 citations
• Gastroenteropancreatic neuroendocrine tumours 1,754 citations
• Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London 1,754 citations
• Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma 1,752 citations
• Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study 1,751 citations
• Small vessel disease: mechanisms and clinical implications 1,751 citations
• Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study 1,751 citations
• Diagnostic criteria for malnutrition – An ESPEN Consensus Statement 1,750 citations
• Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis 1,750 citations
• Population Trends in the Incidence and Outcomes of Acute Myocardial Infarction 1,749 citations
• The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment 1,749 citations
• Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011 1,749 citations
• Guidelines for the management of atrial fibrillation 1,748 citations
• Prevalence of Depression During Pregnancy: Systematic Review 1,748 citations
• The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 1,747 citations
• Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis 1,747 citations
• Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients 1,747 citations
• Neurobiology of emotion perception II: implications for major psychiatric disorders 1,746 citations
• Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis 1,746 citations
• Teaching Surgical Skills — Changes in the Wind 1,745 citations
• Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans 1,745 citations
• Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection 1,745 citations
• Leptin Regulates Bone Formation via the Sympathetic Nervous System 1,744 citations
• Prevalence of Total Hip and Knee Replacement in the United States 1,743 citations
• Modern Epidemiology 3rd edition 1,743 citations
• Good urodynamic practices: Uroflowmetry, filling cystometry, and pressure‐flow studies** 1,741 citations
• Personality, Gender, and Age in the Language of Social Media: The Open-Vocabulary Approach 1,741 citations
• Cost of disorders of the brain in Europe 2010 1,741 citations
• Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer 1,740 citations
• Defining Advance Care Planning for Adults: A Consensus Definition From a Multidisciplinary Delphi Panel 1,740 citations
• Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes 1,740 citations
• Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury 1,739 citations
• The clinical implications of endothelial dysfunction 1,739 citations
• A direct demonstration of functional specialization in human visual cortex 1,738 citations
• Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor 1,738 citations
• A brief self-administered questionnaire to determine functional capacity (The Duke Activity Status Index) 1,738 citations
• Transfusion Strategies for Acute Upper Gastrointestinal Bleeding 1,738 citations
• Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction 1,738 citations
• KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary 1,737 citations
• Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial 1,737 citations
• Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation 1,737 citations
• Explaining heterogeneity in meta-analysis: a comparison of methods 1,737 citations
• Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure 1,736 citations
• GRIPP2 reporting checklists: tools to improve reporting of patient and public involvement in research 1,736 citations
• Functional genomics reveal that the serine synthesis pathway is essential in breast cancer 1,735 citations
• Viral hepatitis B 1,735 citations
• Sparse Representation for Color Image Restoration 1,735 citations
• Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial 1,734 citations
• Trends in the Prevalence of Developmental Disabilities in US Children, 1997–2008 1,734 citations
• Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study 1,734 citations
• Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics” 1,733 citations
• Fractionating theory of mind: A meta-analysis of functional brain imaging studies 1,733 citations
• The Human Serum Metabolome 1,733 citations
• Effects of a Palliative Care Intervention on Clinical Outcomes in Patients With Advanced Cancer 1,733 citations
• Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis 1,733 citations
• Exposure of the U.S. Population to Bisphenol A and 4- <i>tertiary</i> -Octylphenol: 2003–2004 1,732 citations
• CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues 1,732 citations
• Use of a Continuous-Flow Device in Patients Awaiting Heart Transplantation 1,732 citations
• MesoNet: a Compact Facial Video Forgery Detection Network 1,731 citations
• The landscape of cancer genes and mutational processes in breast cancer 1,729 citations
• Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial 1,728 citations
• Six new loci associated with body mass index highlight a neuronal influence on body weight regulation 1,728 citations
• Cardiovascular Risk Factors in Childhood and Carotid Artery Intima-Media Thickness in Adulthood 1,727 citations
• Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 1,727 citations
• Levels of selected carcinogens and toxicants in vapour from electronic cigarettes 1,726 citations
• Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy 1,725 citations
• New genetic loci link adipose and insulin biology to body fat distribution 1,724 citations
• The Development and Well‐Being Assessment: Description and Initial Validation of an Integrated Assessment of Child and Adolescent Psychopathology 1,723 citations
• Recent advances in 3D printing of biomaterials 1,723 citations
• The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 1,723 citations
• The Controversial Role of Human Gut Lachnospiraceae 1,723 citations
• Monitoring Sedation Status Over Time in ICU Patients 1,722 citations
• Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial 1,721 citations
• Cytotoxic CD8+ T cells in cancer and cancer immunotherapy 1,721 citations
• Electronic meeting systems 1,720 citations
• Recommendations on Angiographic Revascularization Grading Standards for Acute Ischemic Stroke 1,720 citations
• Person-Centered Care — Ready for Prime Time 1,720 citations
• Common variants conferring risk of schizophrenia 1,720 citations
• Guidance on how to develop complex interventions to improve health and healthcare 1,719 citations
• Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial 1,718 citations
• The genome sequence of the filamentous fungus Neurospora crassa 1,718 citations
• Non-local sparse models for image restoration 1,718 citations
• KRAS ^G12C Inhibition with Sotorasib in Advanced Solid Tumors 1,718 citations
• Association between Microdeletion and Microduplication at 16p11.2 and Autism 1,717 citations
• Intestinal permeability – a new target for disease prevention and therapy 1,716 citations
• The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) 1,716 citations
• Heart Failure: Preventing Disease and Death Worldwide 1,714 citations
• Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC 1,714 citations
• The gut microbiome in atherosclerotic cardiovascular disease 1,713 citations
• Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017 1,713 citations
• <i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas 1,712 citations
• Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study 1,712 citations
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin 1,710 citations
• 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease 1,710 citations
• Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial 1,710 citations
• Function in the human connectome: Task-fMRI and individual differences in behavior 1,709 citations
• A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis 1,709 citations
• Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial 1,709 citations
• Acute kidney injury 1,708 citations
• Redefining Oxidative Stress 1,707 citations
• Comparative Genomics of the Eukaryotes 1,707 citations
• The Oslo definitions for coeliac disease and related terms 1,707 citations
• Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease 1,707 citations
• Death on the battlefield (2001–2011) 1,706 citations
• Cardia: study design, recruitment, and some characteristics of the examined subjects 1,705 citations
• SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe 1,705 citations
• Transluminal Placement of Endovascular Stent-Grafts for the Treatment of Descending Thoracic Aortic Aneurysms 1,704 citations
• Decisions from Experience and the Effect of Rare Events in Risky Choice 1,704 citations
• Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis 1,704 citations
• ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease 1,704 citations
• Adjuvant Olaparib for Patients with <i>BRCA1</i> - or <i>BRCA2</i> -Mutated Breast Cancer 1,704 citations
• Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude 1,703 citations
• Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study 1,702 citations
• An objective and standardized test of hand function. 1,701 citations
• Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in <i>NOTCH1</i> 1,701 citations
• Diuretic Strategies in Patients with Acute Decompensated Heart Failure 1,701 citations
• Pathologic Classification of Diabetic Nephropathy 1,699 citations
• Defeating Alzheimer's disease and other dementias: a priority for European science and society 1,699 citations
• Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review 1,697 citations
• Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes 1,695 citations
• Molecular Mechanisms of Human Hypertension 1,695 citations
• 2023 ESC Guidelines for the management of endocarditis 1,695 citations
• Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission 1,694 citations
• Machiavellian Intelligence: Social Expertise and the Evolution of Intellect in Monkeys, Apes, and Humans 1,694 citations
• Toxicity Testing in the 21st Century: A Vision and a Strategy 1,693 citations
• Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care 1,692 citations
• Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis 1,691 citations
• Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma 1,691 citations
• The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors 1,690 citations
• Acute Renal Failure After Coronary Intervention 1,689 citations
• Human papillomavirus type distribution in invasive cervical cancer and high‐grade cervical lesions: A meta‐analysis update 1,689 citations
• Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe 1,689 citations
• Longitudinal Follow-up and Outcomes Among a Population With Chronic Kidney Disease in a Large Managed Care Organization 1,689 citations
• Measurement and Interpretation of the Ankle-Brachial Index 1,689 citations
• Integrating Quantitative and Qualitative Results in Health Science Mixed Methods Research Through Joint Displays 1,689 citations
• Enhancing solar cell efficiency: the search for luminescent materials as spectral converters 1,688 citations
• Gut Microbiota in Cardiovascular Health and Disease 1,688 citations
• Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance 1,687 citations
• A simultaneous evaluation of 10 commonly used physical activity questionnaires 1,686 citations
• Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome 1,686 citations
• Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage 1,686 citations
• Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer 1,686 citations
• Ambient Particulate Air Pollution and Daily Mortality in 652 Cities 1,686 citations
• Review on uremic toxins: Classification, concentration, and interindividual variability 1,685 citations
• Randomized Multicenter Trial of Sentinel Node Biopsy Versus Standard Axillary Treatment in Operable Breast Cancer: The ALMANAC Trial 1,685 citations
• Loss of Independence in Activities of Daily Living in Older Adults Hospitalized with Medical Illnesses: Increased Vulnerability with Age 1,684 citations
• Natural oligomers of the amyloid-β protein specifically disrupt cognitive function 1,684 citations
• Olaparib Monotherapy in Patients With Advanced Cancer and a Germline <i>BRCA1/2</i> Mutation 1,684 citations
• The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions 1,683 citations
• The SCARE Statement: Consensus-based surgical case report guidelines 1,683 citations
• DNA repair pathways as targets for cancer therapy 1,682 citations
• Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome 1,682 citations
• Registers of the Swedish total population and their use in medical research 1,680 citations
• Scientific discovery in the age of artificial intelligence 1,680 citations
• Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group 1,679 citations
• A library of atomically thin metal chalcogenides 1,679 citations
• A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures 1,679 citations
• GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community 1,679 citations
• PhenoScanner: a database of human genotype–phenotype associations 1,678 citations
• Discrimination and Calibration of Clinical Prediction Models 1,678 citations
• Measurement of Residual Breast Cancer Burden to Predict Survival After Neoadjuvant Chemotherapy 1,677 citations
• Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 1,676 citations
• Reactivity of a monoclonal antibody with human ovarian carcinoma. 1,676 citations
• Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) 1,676 citations
• Attachment and reflective function: Their role in self-organization 1,676 citations
• The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System: Risk stratification based on Wound, Ischemia, and foot Infection (WIfI) 1,676 citations
• Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function 1,675 citations
• Large-scale association analysis identifies new risk loci for coronary artery disease 1,675 citations
• A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus 1,675 citations
• Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study 1,675 citations
• The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation 1,674 citations
• The ALICE experiment at the CERN LHC 1,674 citations
• TinyBERT: Distilling BERT for Natural Language Understanding 1,674 citations
• Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases 1,673 citations
• Association of Gestational Weight Gain With Maternal and Infant Outcomes 1,672 citations
• 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management 1,671 citations
• Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE) 1,670 citations
• Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology 1,670 citations
• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. 1,669 citations
• Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial 1,669 citations
• Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging 1,668 citations
• Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016 1,668 citations
• Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome 1,667 citations
• Differential expression of orexin receptors 1 and 2 in the rat brain 1,666 citations
• Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors 1,666 citations
• Effect of carvedilol on survival in severe chronic heart failure 1,666 citations
• Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis 1,665 citations
• The classification of glomerulonephritis in systemic lupus erythematosus revisited 1,665 citations
• Developmental Trajectories of Brain Volume Abnormalities in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder 1,665 citations
• Practical statistics for medical research 1,665 citations
• Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018 1,665 citations
• Antisense Transcription in the Mammalian Transcriptome 1,664 citations
• Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial 1,664 citations
• Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients 1,664 citations
• Deep learning for smart manufacturing: Methods and applications 1,662 citations
• Role of Imaging in the Staging and Response Assessment of Lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group 1,661 citations
• Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? 1,661 citations

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