Papers.

• Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy 7,516 citations
• The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels 7,496 citations
• Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes 7,491 citations
• Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer 7,489 citations
• Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia 7,486 citations
• Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes 7,445 citations
• Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 7,427 citations
• 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines 7,413 citations
• Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro 7,391 citations
• Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 7,357 citations
• Heart Disease and Stroke Statistics—2012 Update 7,243 citations
• Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association 7,242 citations
• 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes 7,221 citations
• Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery 7,208 citations
• 2018 ESC/EACTS Guidelines on myocardial revascularization 7,193 citations
• Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease 7,190 citations
• 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation 7,151 citations
• Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals 7,139 citations
• 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults 7,116 citations
• Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment 7,109 citations
• SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials 7,107 citations
• Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury 7,106 citations
• A Rapid Bootstrap Algorithm for the RAxML Web Servers 7,106 citations
• Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes 7,106 citations
• Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions 7,104 citations
• IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040 7,076 citations
• Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis 7,074 citations
• Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography 7,055 citations
• A metagenome-wide association study of gut microbiota in type 2 diabetes 7,016 citations
• Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction 7,005 citations
• Global quantification of mammalian gene expression control 6,967 citations
• ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC 6,915 citations
• Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure 6,901 citations
• Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction 6,892 citations
• ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation 6,847 citations
• Intravenous Fluids and Acute Kidney Injury 6,844 citations
• Bariatric Surgery 6,811 citations
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 6,811 citations
• Bounding the role of black carbon in the climate system: A scientific assessment 6,787 citations
• Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes 6,777 citations
• Factors associated with COVID-19-related death using OpenSAFELY 6,761 citations
• Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes 6,751 citations
• Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging 6,734 citations
• Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade 6,732 citations
• Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 6,728 citations
• Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 6,721 citations
• Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer 6,696 citations
• Global causes of maternal death: a WHO systematic analysis 6,692 citations
• Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis 6,678 citations
• Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 6,658 citations
• The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) 6,655 citations
• Endothelial cell infection and endotheliitis in COVID-19 6,652 citations
• Heart Disease and Stroke Statistics—2016 Update 6,648 citations
• Regression Modeling Strategies 6,638 citations
• The American Academy of Sleep Medicine (AASM) Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications 6,633 citations
• 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides 6,623 citations
• Comprehensive molecular characterization of gastric adenocarcinoma 6,576 citations
• Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer 6,573 citations
• Process evaluation of complex interventions: Medical Research Council guidance 6,560 citations
• Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial 6,558 citations
• Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure 6,548 citations
• Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data 6,536 citations
• Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 6,530 citations
• 2016 European Guidelines on cardiovascular disease prevention in clinical practice 6,527 citations
• Particulate Matter Air Pollution and Cardiovascular Disease 6,521 citations
• Improving the Quality of Web Surveys: The Checklist for Reporting Results of Internet E-Surveys (CHERRIES) 6,513 citations
• 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults 6,512 citations
• Revised Equations for Estimated GFR From Serum Creatinine in Japan 6,485 citations
• 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS 6,477 citations
• 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS 6,470 citations
• 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice 6,449 citations
• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups 6,440 citations
• Cortical Surface-Based Analysis 6,433 citations
• The Patient Health Questionnaire-2 6,405 citations
• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges 6,389 citations
• Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes 6,387 citations
• A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer 6,385 citations
• Large-Scale Video Classification with Convolutional Neural Networks 6,364 citations
• Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients 6,358 citations
• Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections 6,349 citations
• 2017 ESC/EACTS Guidelines for the management of valvular heart disease 6,329 citations
• Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 6,323 citations
• The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure 6,278 citations
• The Immune Landscape of Cancer 6,277 citations
• Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer 6,267 citations
• Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer 6,263 citations
• Prevalence of Diagnosed Atrial Fibrillation in Adults 6,235 citations
• Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries 6,234 citations
• Dementia prevention, intervention, and care 6,226 citations
• 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines 6,223 citations
• The International HapMap Project 6,188 citations
• Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis 6,175 citations
• Heart Disease and Stroke Statistics—2011 Update 6,172 citations
• Cancer treatment and survivorship statistics, 2016 6,166 citations
• Cross-cultural adaptation of health-related quality of life measures: Literature review and proposed guidelines 6,118 citations
• Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association 6,095 citations
• Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy 6,091 citations
• The PHQ-9: A New Depression Diagnostic and Severity Measure 6,087 citations
• Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science 6,068 citations
• Roary: rapid large-scale prokaryote pan genome analysis 6,061 citations
• Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease 6,061 citations
• Social Network Analysis: A Handbook. 6,058 citations
• The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. 6,058 citations
• Measuring the thickness of the human cerebral cortex from magnetic resonance images 6,055 citations
• Expert consensus document on arterial stiffness: methodological issues and clinical applications 6,038 citations
• Radiomics: Extracting more information from medical images using advanced feature analysis 6,037 citations
• The Genome Sequence of <i>Drosophila melanogaster</i> 6,036 citations
• Biological properties of extracellular vesicles and their physiological functions 6,035 citations
• Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association 6,027 citations
• Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes 6,021 citations
• Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies 6,019 citations
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 6,015 citations
• A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance 6,008 citations
• ILAE Official Report: A practical clinical definition of epilepsy 6,003 citations
• The GTEx Consortium atlas of genetic regulatory effects across human tissues 5,992 citations
• Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction 5,961 citations
• Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma 5,921 citations
• No Adjustments Are Needed for Multiple Comparisons 5,917 citations
• 2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 5,917 citations
• Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia 5,913 citations
• Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy 5,903 citations
• REVIEW OF COMMUNITY-BASED RESEARCH: Assessing Partnership Approaches to Improve Public Health 5,896 citations
• Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) 5,878 citations
• An Integrated Genomic Analysis of Human Glioblastoma Multiforme 5,872 citations
• Fourth universal definition of myocardial infarction (2018) 5,855 citations
• Heart Disease and Stroke Statistics—2021 Update 5,838 citations
• 2007 Guidelines for the Management of Arterial Hypertension 5,834 citations
• Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 5,834 citations
• Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A reevaluation of the Life Orientation Test. 5,832 citations
• Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure 5,825 citations
• Heart Disease and Stroke Statistics—2015 Update 5,825 citations
• Relatives of the Impaired Elderly: Correlates of Feelings of Burden 5,818 citations
• Global aetiology and epidemiology of type 2 diabetes mellitus and its complications 5,793 citations
• Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial 5,791 citations
• Interaction terms in logit and probit models 5,787 citations
• EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update 5,784 citations
• Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer 5,784 citations
• Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate 5,775 citations
• PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement 5,763 citations
• Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 5,763 citations
• Docetaxel plus Prednisone or Mitoxantrone plus Prednisone for Advanced Prostate Cancer 5,744 citations
• The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans 5,734 citations
• Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A reevaluation of the Life Orientation Test. 5,731 citations
• Definition and classification of cancer cachexia: an international consensus 5,722 citations
• Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia 5,720 citations
• Radiomics: the bridge between medical imaging and personalized medicine 5,681 citations
• DeepLabCut: markerless pose estimation of user-defined body parts with deep learning 5,680 citations
• Graph neural networks: A review of methods and applications 5,675 citations
• 2013 ESH/ESC Guidelines for the management of arterial hypertension 5,673 citations
• Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease 5,628 citations
• The cortical organization of speech processing 5,614 citations
• Heart Disease and Stroke Statistics—2010 Update 5,609 citations
• Brain development during childhood and adolescence: a longitudinal MRI study 5,600 citations
• The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines 5,598 citations
• 2021 ESC/EACTS Guidelines for the management of valvular heart disease 5,563 citations
• Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors 5,556 citations
• Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial 5,545 citations
• Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II 5,538 citations
• Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer 5,537 citations
• Audit and feedback: effects on professional practice and healthcare outcomes 5,535 citations
• RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow 5,532 citations
• A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 5,525 citations
• Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study 5,519 citations
• EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection 5,481 citations
• Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration 5,474 citations
• The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement 5,469 citations
• Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic 5,468 citations
• Mechanisms linking obesity to insulin resistance and type 2 diabetes 5,466 citations
• Erlotinib in Previously Treated Non–Small-Cell Lung Cancer 5,459 citations
• El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis 5,440 citations
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report 5,435 citations
• Clinical End Points in Coronary Stent Trials 5,430 citations
• Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol 5,421 citations
• Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. 5,419 citations
• Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study 5,419 citations
• Lecanemab in Early Alzheimer’s Disease 5,416 citations
• Achieving Integration in Mixed Methods Designs—Principles and Practices 5,396 citations
• Food, nutrition, physical activity, and the prevention of cancer: a global perspective 5,392 citations
• The functional anatomy of basal ganglia disorders 5,381 citations
• Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group 5,378 citations
• Osimertinib in Untreated <i>EGFR</i> -Mutated Advanced Non–Small-Cell Lung Cancer 5,376 citations
• Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer 5,365 citations
• Ti based biomaterials, the ultimate choice for orthopaedic implants – A review 5,364 citations
• Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence 5,361 citations
• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq 5,358 citations
• Dapagliflozin in Patients with Chronic Kidney Disease 5,353 citations
• The Worldwide Prevalence of ADHD: A Systematic Review and Metaregression Analysis 5,351 citations
• Comparison of Mortality in All Patients on Dialysis, Patients on Dialysis Awaiting Transplantation, and Recipients of a First Cadaveric Transplant 5,348 citations
• Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus 5,341 citations
• The PRISMA 2020 statement: an updated guideline for reporting systematic reviews 5,341 citations
• Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019 5,340 citations
• Global prevalence of dementia: a Delphi consensus study 5,329 citations
• Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia 5,319 citations
• Increased oxidative stress in obesity and its impact on metabolic syndrome 5,306 citations
• Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention 5,300 citations
• Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen 5,279 citations
• Rules for Scoring Respiratory Events in Sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events 5,261 citations
• The PHQ-8 as a measure of current depression in the general population 5,257 citations
• Visual Genome: Connecting Language and Vision Using Crowdsourced Dense Image Annotations 5,247 citations
• Geodesic Active Contours 5,247 citations

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