Papers.

• Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society 2,762 citations
• Distinct brain networks for adaptive and stable task control in humans 2,761 citations
• Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes 2,761 citations
• The Basic Science of Articular Cartilage: Structure, Composition, and Function 2,759 citations
• Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 2,758 citations
• Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease 2,757 citations
• Evidence for decreasing quality of semen during past 50 years. 2,756 citations
• Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis 2,755 citations
• Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials 2,753 citations
• The Role of Actigraphy in the Study of Sleep and Circadian Rhythms 2,752 citations
• The MicroRNA Spectrum in 12 Body Fluids 2,752 citations
• Spironolactone for Heart Failure with Preserved Ejection Fraction 2,751 citations
• Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference 2,750 citations
• Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis 2,749 citations
• Screening for Undernutrition in Geriatric Practice: Developing the Short-Form Mini-Nutritional Assessment (MNA-SF) 2,748 citations
• Global Distribution of Perfluorooctane Sulfonate in Wildlife 2,747 citations
• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer 2,746 citations
• Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings 2,743 citations
• Colonic Health: Fermentation and Short Chain Fatty Acids 2,742 citations
• 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation 2,742 citations
• Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction 2,742 citations
• A Polymer-Based, Paclitaxel-Eluting Stent in Patients with Coronary Artery Disease 2,741 citations
• OncoKB: A Precision Oncology Knowledge Base 2,730 citations
• The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm 2,730 citations
• Understanding normal and impaired word reading: Computational principles in quasi-regular domains. 2,728 citations
• A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease 2,728 citations
• The Role of Stress Echocardiography in Valvular Heart Disease: A Current Appraisal 2,728 citations
• B cells and tertiary lymphoid structures promote immunotherapy response 2,728 citations
• Bosentan Therapy for Pulmonary Arterial Hypertension 2,727 citations
• High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis 2,722 citations
• Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer 2,721 citations
• Diet and Lifestyle Recommendations Revision 2006 2,720 citations
• 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults 2,719 citations
• European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support 2,718 citations
• Clinical-grade computational pathology using weakly supervised deep learning on whole slide images 2,717 citations
• Diabetes and Atherosclerosis 2,716 citations
• GRADE guidelines 6. Rating the quality of evidence—imprecision 2,716 citations
• Molecular theory of gases and liquids 2,715 citations
• 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum 2,715 citations
• AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer 2,714 citations
• A psychomotor stimulant theory of addiction. 2,713 citations
• A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer 2,712 citations
• The Law of Attrition 2,711 citations
• A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress 2,709 citations
• Multisystem Inflammatory Syndrome in U.S. Children and Adolescents 2,709 citations
• A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer 2,707 citations
• Subgenual prefrontal cortex abnormalities in mood disorders 2,706 citations
• Whole genomes redefine the mutational landscape of pancreatic cancer 2,705 citations
• A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension 2,705 citations
• PROBAST: A Tool to Assess the Risk of Bias and Applicability of Prediction Model Studies 2,704 citations
• The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline 2,701 citations
• Dialysis Dose and Intradialytic Hypotension: Results from the HEMO Study 2,699 citations
• Alzheimer disease in the United States (2010–2050) estimated using the 2010 census 2,699 citations
• Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women 2,699 citations
• ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) 2,698 citations
• International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an International workshop 2,695 citations
• Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis 2,694 citations
• Donanemab in Early Symptomatic Alzheimer Disease 2,694 citations
• An integrated map of structural variation in 2,504 human genomes 2,693 citations
• European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease 2,693 citations
• Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group 2,693 citations
• Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes 2,692 citations
• Prevention of VTE in Nonsurgical Patients 2,691 citations
• Studies Comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for Assessment of Pain Intensity in Adults: A Systematic Literature Review 2,690 citations
• 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure 2,690 citations
• Fracture and Dislocation Classification Compendium—2018 2,688 citations
• The Global Methane Budget 2000-2017 2,687 citations
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ 2,687 citations
• Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome 2,684 citations
• Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer 2,684 citations
• Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 2,684 citations
• Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial 2,682 citations
• Towards circular economy implementation: a comprehensive review in context of manufacturing industry 2,682 citations
• How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology 2,681 citations
• The projected effect of risk factor reduction on Alzheimer's disease prevalence 2,681 citations
• Identification of common genetic risk variants for autism spectrum disorder 2,679 citations
• A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong 2,677 citations
• Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States 2,675 citations
• Situating the default-mode network along a principal gradient of macroscale cortical organization 2,675 citations
• Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial 2,674 citations
• Gene networks involved in drought stress response and tolerance 2,674 citations
• Origins and functions of positive and negative affect: A control-process view. 2,672 citations
• Global Public Health Burden of Heart Failure 2,670 citations
• Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia 2,665 citations
• Internal validation of predictive models 2,664 citations
• Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma 2,664 citations
• 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer 2,661 citations
• Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma 2,660 citations
• Stereotaxic Display of Brain Lesions 2,659 citations
• Guidelines for the Primary Prevention of Stroke 2,658 citations
• Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 2,658 citations
• Calculating the sample size required for developing a clinical prediction model 2,655 citations
• Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants 2,652 citations
• Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer 2,652 citations
• Appropriate Physical Activity Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults 2,651 citations
• Attention regulation and monitoring in meditation 2,650 citations
• Global Prevalence of Autism and Other Pervasive Developmental Disorders 2,648 citations
• A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management 2,641 citations
• Endothelial Function and Dysfunction 2,640 citations
• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease 2,640 citations
• Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 2,640 citations
• Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up 2,639 citations
• ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 2,637 citations
• Third Universal Definition of Myocardial Infarction 2,637 citations
• Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer 2,636 citations
• Expanded encyclopaedias of DNA elements in the human and mouse genomes 2,636 citations
• Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease 2,635 citations
• Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016 2,634 citations
• 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction 2,634 citations
• Metaverse beyond the hype: Multidisciplinary perspectives on emerging challenges, opportunities, and agenda for research, practice and policy 2,633 citations
• 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) 2,633 citations
• Positron emission tomographic studies of the cortical anatomy of single-word processing 2,629 citations
• Updated research nosology for HIV-associated neurocognitive disorders 2,628 citations
• The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene 2,626 citations
• Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial 2,622 citations
• A taxonomy of behavior change techniques used in interventions. 2,621 citations
• 2024 ESC Guidelines for the management of chronic coronary syndromes 2,620 citations
• Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer 2,619 citations
• Adiponectin and Adiponectin Receptors 2,617 citations
• Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis 2,616 citations
• Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial 2,615 citations
• The rise of “big data” on cloud computing: Review and open research issues 2,615 citations
• Jasmonates: biosynthesis, perception, signal transduction and action in plant stress response, growth and development. An update to the 2007 review in Annals of Botany 2,614 citations
• RE-AIM Planning and Evaluation Framework: Adapting to New Science and Practice With a 20-Year Review 2,614 citations
• Attention and Self-Regulation : A Control-Theory Approach to Human Behavior 2,612 citations
• ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article 2,612 citations
• Beyond PICO 2,611 citations
• 2015 ESC Guidelines for the diagnosis and management of pericardial diseases 2,610 citations
• The Community Earth System Model (CESM) Large Ensemble Project: A Community Resource for Studying Climate Change in the Presence of Internal Climate Variability 2,606 citations
• 2003 European society of hypertension - European Society of Cardiology guidelines for the management of arterial hypertension 2,605 citations
• Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease 2,605 citations
• A conceptual framework for implementation fidelity 2,604 citations
• Introduction to the Analysis of Survival Data in the Presence of Competing Risks 2,601 citations
• Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure 2,601 citations
• Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes 2,600 citations
• Systematic identification of genomic markers of drug sensitivity in cancer cells 2,599 citations
• Agriculture Development, Pesticide Application and Its Impact on the Environment 2,599 citations
• Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus 2,596 citations
• Consensus statement on the pathology of IgG4-related disease 2,595 citations
• Antitumor Activity of Thalidomide in Refractory Multiple Myeloma 2,595 citations
• Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research 2,594 citations
• Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis 2,593 citations
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci 2,593 citations
• Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 2,593 citations
• Mediators and Moderators of Treatment Effects in Randomized Clinical Trials 2,591 citations
• Probability Concepts in Engineering Planning and Design 2,590 citations
• Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus 2,590 citations
• Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer 2,590 citations
• Summarizing systematic reviews 2,590 citations
• Type 2 diabetes mellitus 2,590 citations
• The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus 2,589 citations
• Trastuzumab — Mechanism of Action and Use in Clinical Practice 2,589 citations
• Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial 2,588 citations
• Randomized, Controlled Trial of an Intervention for Toddlers With Autism: The Early Start Denver Model 2,588 citations
• Lung cancer 2,586 citations
• Nonalcoholic Fatty Liver Disease 2,585 citations
• First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer 2,585 citations
• 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus 2,584 citations
• Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma 2,583 citations
• “Mental health literacy”: a survey of the public's ability to recognise mental disorders and their beliefs about the effectiveness of treatment 2,582 citations
• Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes 2,581 citations
• Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update 2,580 citations
• Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies 2,577 citations
• Checking consistency in mixed treatment comparison meta‐analysis 2,575 citations
• UALCAN: An update to the integrated cancer data analysis platform 2,573 citations
• Sources, Fate and Transport of Perfluorocarboxylates 2,571 citations
• Mechanical properties of graphene and graphene-based nanocomposites 2,570 citations
• Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy 2,569 citations
• Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma 2,569 citations
• Mutations in the <i>FUS/TLS</i> Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis 2,568 citations
• Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study 2,563 citations
• Angiotensin-converting enzyme 2 protects from severe acute lung failure 2,562 citations
• Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves 2,562 citations
• ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities 2,559 citations
• 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association 2,559 citations
• The Mutational Landscape of Head and Neck Squamous Cell Carcinoma 2,556 citations
• Diagnostic criteria for mild cognitive impairment in Parkinson's disease: <i>Movement</i> Disorder Society Task Force guidelines 2,554 citations
• Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors 2,553 citations
• Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis 2,552 citations
• Global Signatures and Dynamical Origins of the Little Ice Age and Medieval Climate Anomaly 2,552 citations
• The Children's Sleep Habits Questionnaire (CSHQ): Psychometric Properties of A Survey Instrument for School-Aged Children 2,552 citations
• Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography 2,551 citations
• Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial 2,550 citations
• Framing, Agenda Setting, and Priming: The Evolution of Three Media Effects Models 2,548 citations
• Specific reading disability (dyslexia): what have we learned in the past four decades? 2,548 citations
• MassBank: a public repository for sharing mass spectral data for life sciences 2,547 citations
• Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial 2,547 citations
• Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men 2,546 citations
• Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases 2,545 citations
• Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases 2,544 citations
• Association of reactive oxygen species levels and radioresistance in cancer stem cells 2,544 citations
• Non-specific low back pain 2,543 citations
• Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer 2,541 citations
• Prevalence of obstructive sleep apnea in the general population: A systematic review 2,541 citations
• K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease 2,541 citations
• Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors 2,540 citations
• Model for end-stage liver disease (MELD) and allocation of donor livers 2,540 citations
• Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer 2,539 citations
• Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer 2,539 citations
• SARS-CoV-2 Infection in Children 2,539 citations

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