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Cancer therapeutics and mechanisms
TopicLeading institutions, researchers & key papers
This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
174
Works
IDs:OpenAlex
How has Cancer therapeutics and mechanisms's publication output changed over time?
ScholarIQpublication output · 2005–2021
Output declined50% over the shown period — from 2 works in 2005 to 1 in 2021.
2
2
1
1
1
1
1
1
1
1
2005200620102012201320162017201920202021
What are the most-cited papers on Cancer therapeutics and mechanisms?
ScholarIQmost cited works
Topoisomerase I inhibitors: camptothecins and beyond
Yves Pommier
S160464432. 20062,258 CitationsOPEN ACCESS
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
Yves Pommier, Elisabetta Leo, Hongliang Zhang, Christophe Marchand
S85134406. 20101,842 CitationsOPEN ACCESS
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Yves Pommier, Yilun Sun, Shar-yin N. Huang, John L. Nitiss
S196724125. 2016982 CitationsOPEN ACCESS
Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Noritaka Tanaka, Jessica J. Lin, Chendi Li, Meagan B. Ryan, Junbing Zhang, Lesli A. Kiedrowski, Alexa Michel, Mohammed U. Syed, Katerina A. Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F. Gainor, Samuel J. Klempner, Jochen K. Lennerz, Giulia Siravegna, Liron Bar‐Peled, Aaron N. Hata, Rebecca S. Heist, Ryan B. Corcoran
Cancer Discovery. 2021526 CitationsOPEN ACCESS
Where is Cancer therapeutics and mechanisms research published, and who funds it?
ScholarIQvenues & funding sources
TOP JOURNALS
S1604644322,258
S851344061,842
S196724125982
S118914585837
S162030435791
TOP FUNDERS
National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
Funder breakdown is a member featureSign up free to unlock
How much of the research on Cancer therapeutics and mechanisms is open access?
ScholarIQopen access share
67%OPEN ACCESS
Gold
0%
Green
20%
Hybrid
20%
Bronze
27%
Closed
33%
Related on ScholarIQ
<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
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Topoisomerase I inhibitors: camptothecins and beyond
Paper
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
Paper
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