Genetic factors in colorectal cancer

TopicLeading institutions, researchers & key papers

This cluster of papers focuses on the comprehensive molecular characterization, genetic testing, and hereditary syndromes related to colorectal cancer. It explores topics such as microsatellite instability, DNA mismatch repair, Lynch syndrome, adjuvant chemotherapy, and the molecular basis of polyposis syndromes. The research also delves into the implications for cancer risk assessment and management.

421

Works

IDs:OpenAlex

How has Genetic factors in colorectal cancer's publication output changed over time?

ScholarIQpublication output · 2007–2019

Output grew100% over the shown period — from 1 works in 2007 to 2 in 2019.

2007200820092010201120122013201520172019

What are the most-cited papers on Genetic factors in colorectal cancer?

ScholarIQmost cited works

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le, Jennifer N. Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Laveet K. Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon Luber, Fay Wong, Nilofer S. Azad, Agnieszka A. Rucki, Dan Laheru, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Tim F. Greten, Austin G. Duffy, Kristen K. Ciombor, Aleksandra Eyring, Bao H. Lam, Andrew K. Joe, Soonmo Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian F. Meyer, Shibin Zhou, Richard M. Goldberg, Deborah K. Armstrong, Katherine M. Bever, Amanda N. Fader, Janis M. Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, James R. Eshleman, Bert Vogelstein, Robert A. Anders, Luis A. Díaz

Science. 20176,732 Citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton, David Sidransky, James R. Eshleman, Randall W. Burt, Stephen J. Meltzer, Miguel A. Rodrı́guez-Bigas, Riccardo Fodde, Guglielmina Nadia Ranzani, Sudhir Srivastava

PubMed. 19984,130 Citations

Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

Asad Umar, C. Richard Boland, Jonathan P. Terdiman, Sapna Syngal, Albert de la Chapelle, Josef Rüschoff, Richard Fishel, Noralene M. Lindor, Lawrence J. Burgart, Richard C. Hamelin, Stanley R. Hamilton, Robert A. Hiatt, Jeremy R. Jass, Annika Lindblom, Henry T. Lynch, Païvi Peltomäki, Scott D. Ramsey, Miguel A. Rodrı́guez-Bigas, Hans F. A. Vasen, Ernest T. Hawk, J. Carl Barrett, Andrew N. Freedman, Sudhir Srivastava

JNCI Journal of the National Cancer Institute. 20043,196 CitationsOPEN ACCESS

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Fredrick S. Leach, Nicholas C. Nicolaides, Nickolas Papadopoulos, Bo Liu, Jin Jen, Ramon Parsons, Païvi Peltomäki, Pertti Sistonen, Lauri A. Aaltonen, Minna Nyström, Xin‐Yuan Guan, Ji Zhang, Paul S. Meltzer, Jingwei Yu, Fa‐Ten Kao, David J. Chen, Karen Cerosaletti, R. E. K. Fournier, S. Todd, Tracey Lewis, Robin J. Leach, Susan L. Naylor, Jean Weissenbach, Jukka‐Pekka Mecklin, Heikki Järvinen, Gloria M. Petersen, Stanley R. Hamilton, Jane Green, Jeremy R. Jass, Patrice Watson, Henry T. Lynch, Jeffrey M. Trent, Albert de la Chapelle, Kenneth W. Kinzler, Bert Vogelstein

S110447773. 19932,286 Citations

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Jakob Nikolas Kather, Alexander T. Pearson, Niels Halama, Dirk Jäger, Jeremias Krause, Sven H. Loosen, Alexander Marx, Peter Boor, Frank Tacke, Ulf P. Neumann, Heike I. Grabsch, Takaki Yoshikawa, Hermann Brenner, Jenny Chang‐Claude, Michael Hoffmeister, Christian Trautwein, Tom Luedde

Nature Medicine. 20191,445 CitationsOPEN ACCESS