Natural Compounds in Disease Treatment

TopicLeading institutions, researchers & key papers

This cluster of papers explores the therapeutic potential of herbal medicines, focusing on compounds such as Celastrol and Triptolide derived from Thunder God Vine and Tripterygium wilfordii Hook F. The research covers their applications in treating inflammatory disorders, cancer, and neurodegenerative diseases, as well as their potential in targeting specific pathways like NF-?B, inducing apoptosis, and acting as antioxidants. Additionally, the cluster delves into the use of these herbal medicines in conditions like rheumatoid arthritis through drug targeting approaches.

Works

IDs:OpenAlex

How has Natural Compounds in Disease Treatment's publication output changed over time?

ScholarIQpublication output · 2014–2023

Output grew0% over the shown period — from 1 works in 2014 to 1 in 2023.

2014201520162017201820192020202120222023

What are the most-cited papers on Natural Compounds in Disease Treatment?

ScholarIQmost cited works

Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial

Qianwen Lv, Wen Zhang, Qun Shi, Wenjie Zheng, Xin Li, Hua Chen, Qingjun Wu, Wanlan Jiang, Hongbin Li, Lu Gong, Wei Wei, Hui Liu, Aijing Liu, Hong-tao Jin, Junxiang Wang, Xiumei Liu, Zhenbin Li, Bin Liu, Min Shen, Qian Wang, Xiangni Wu, Di Liang, Yufeng Yin, Yun-yun Fei, SU Jing-mei, Lidan Zhao, Ying Jiang, Jing Li, Fu-lin Tang, Fengchun Zhang, Peter E. Lipsky, Xuan Zhang

Annals of the Rheumatic Diseases. 2014235 Citations

Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies

Cheng Wang, Shu Guang Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li

Biomedicine & Pharmacotherapy. 2023140 CitationsOPEN ACCESS

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy

Qian Gao, Wenwen Shen, Weisong Qin, Chunxia Zheng, Min Zhang, Caihong Zeng, Lingling Wang, J. Wang, Xiaodong Zhu, Zhihong Liu

Nephrology Dialysis Transplantation. 201088 CitationsOPEN ACCESS

Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway

Junjie Yang, Jiayu Liu, Jing Li, Ming Jing, Leiming Zhang, Mengmeng Sun, Qiaoyun Wang, Hongliu Sun, Gui‐Ge Hou, Chunhua Wang, Wenyu Xin

International Immunopharmacology. 202284 CitationsOPEN ACCESS

Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction

Mian Cheng, Gang Wu, Yue Song, Lin Wang, Ling Tu, Lizhi Zhang, Cuntai Zhang